{"id":3193,"date":"2024-10-01T08:34:03","date_gmt":"2024-10-01T12:34:03","guid":{"rendered":"https:\/\/www.trispharma.com\/?p=3193"},"modified":"2024-10-01T08:44:59","modified_gmt":"2024-10-01T12:44:59","slug":"tris-pharmas-once-daily-adhd-medication-onyda-xr-clonidine-hydrochloride-extended-release-oral-suspension-now-available-in-the-united-states","status":"publish","type":"post","link":"https:\/\/www.trispharma.com\/tris-pharmas-once-daily-adhd-medication-onyda-xr-clonidine-hydrochloride-extended-release-oral-suspension-now-available-in-the-united-states\/","title":{"rendered":"Tris Pharma\u2019s Once-Daily ADHD Medication, ONYDA XR (clonidine hydrochloride) Extended-Release Oral Suspension, Now Available in the United States"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text css=&#8221;&#8221;]<\/p>\n<p style=\"text-align: center;\"><em>\u2013 ONYDA XR is the first-and-only liquid non-stimulant ADHD medication available in the United States<\/em><em>\u00a0\u2013<\/em><em>\u00a0<\/em><\/p>\n<p style=\"text-align: center;\"><em>\u2013 Once-a-day, nighttime dosing and extended-release profile fulfill critical unmet needs in pediatric ADHD patients six years and older \u2013<\/em><\/p>\n<p><strong>MONMOUTH JUNCTION, NJ, October 1, 2024 \u2013 Business Wire \u2013 <\/strong>Tris Pharma, Inc. (Tris), a commercial-stage biopharmaceutical company focused on attention deficit hyperactivity disorder (ADHD), pain, addiction and neurological disorders, today announced the commercial availability of ONYDA\u2122 XR (clonidine hydrochloride) extended-release oral suspension. The U.S. Food and Drug Administration (FDA) approved the once-a-day liquid medication with nighttime dosing in May 2024 for the treatment of ADHD as a monotherapy or as an adjunctive therapy to approved central nervous system (CNS) stimulant medications in pediatric patients six years and older.<\/p>\n<p>ONYDA XR is now available through national pharmaceutical wholesalers and patients can fill prescriptions for ONYDA XR through their local pharmacies across the United States.<\/p>\n<p>\u201cNon-stimulant ADHD therapies are an increasingly important option for patients who do not respond adequately to stimulant medications or experience negative side effects from them,\u201d said Manesh Naidu, chief commercial officer at Tris Pharma. \u201cAs ADHD Awareness Month kicks off, we\u2019re especially pleased that ONYDA XR is now available to patients in the United States who might benefit from it as the first-and-only liquid non-stimulant ADHD medication. We look forward to expanding access to this treatment and making a meaningful difference in the lives of those living with ADHD.\u201d<\/p>\n<p>ONYDA XR was developed using Tris Pharma\u2019s proprietary drug-delivery technology to enable a once-a-day extended-release profile, and with its liquid formulation, patients now have an option that allows for easier administration in a range of doses. ONYDA XR is the first-and-only liquid non-stimulant ADHD medication approved in the United States and the only approved non-stimulant ADHD medication with nighttime dosing.<\/p>\n<p>\u201cAs the prevalence of ADHD continues to grow, so does the need for the availability of a wider variety of treatment options that meet the unique and individual needs of patients,\u201d said Rakesh Jain, MD, MPH, clinical professor, Texas Tech University School of Medicine \u2013 Permian Basin. \u201cUntil now, there has not been an extended-release oral suspension non-stimulant option available to people with ADHD who may struggle taking pills or require a longer-acting therapy. The availability of ONYDA XR represents a meaningful advancement in tailoring treatment to the diverse needs of people with ADHD, and I am excited to now have this important additional medicine available for my patients.\u201d<\/p>\n<p>The U.S. FDA approval of ONYDA XR was based on adequate and well-controlled studies of clonidine hydrochloride extended-release tablets. Physicians can learn more at <a href=\"http:\/\/www.onydahcp.com\" target=\"_blank\" rel=\"noopener\">www.onydahcp.com<\/a>.<\/p>\n<p>ONYDA XR is available by prescription to pediatric patients six years and older. More information, including financial support options, is available at <a href=\"http:\/\/www.onyda.com\" target=\"_blank\" rel=\"noopener\">www.onyda.com<\/a>.<\/p>\n<p><strong>About Tris Pharma<br \/>\n<\/strong>Tris Pharma is a privately held, innovation-driven biopharmaceutical company that is applying its drug development capabilities and proprietary technologies to transform the treatment of ADHD, pain, \u00a0addiction and disorders \u00a0of the central nervous system. Tris is an established commercial organization with a robust portfolio of best-in-class ADHD products and a promising pipeline of differentiated, near-term drug candidates. More information is available at\u00a0<a href=\"https:\/\/www.trispharma.com\/\"><strong>www.trispharma.com<\/strong><\/a>\u00a0and on LinkedIn @<a href=\"https:\/\/www.linkedin.com\/company\/tris-pharma\/\" target=\"_blank\" rel=\"noopener\"><strong>TrisPharma<\/strong><\/a>.<\/p>\n<p><strong>ONYDA (Clonidine hydrochloride)<\/strong><\/p>\n<p><strong>INDICATION &amp; IMPORTANT SAFETY INFORMATION<\/strong><\/p>\n<p><strong>\u00a0<\/strong><strong>INDICATION<\/strong><\/p>\n<p>ONYDA XR is a centrally acting alpha2-adrenergic agonist indicated for the treatment of attention deficit hyperactivity disorder (ADHD) as monotherapy or as adjunctive therapy to central nervous system (CNS) stimulant medications in pediatric patients 6 years of age and older.<\/p>\n<p><strong>IMPORTANT SAFETY INFORMATION<\/strong><\/p>\n<p><strong>Contraindications:<\/strong><\/p>\n<ul>\n<li>ONYDA is contraindicated in patients with history of a hypersensitivity reaction to clonidine.<\/li>\n<\/ul>\n<p><strong>\u00a0<\/strong><strong>Warnings &amp; Precautions:<\/strong><\/p>\n<ul>\n<li><strong>Hypotension\/Bradycardia<\/strong>: Treatment with ONYDA XR can cause dose-related decreases in blood pressure and heart rate. Titrate slowly and monitor vital signs frequently in patients at risk for hypotension, heart block, bradycardia, syncope, cardiovascular disease, vascular disease, cerebrovascular disease, or chronic renal failure. In patients who have a history of syncope or may have a condition that predisposes them to syncope, such as hypotension, orthostatic hypotension, bradycardia, or dehydration, advise patients to avoid becoming dehydrated or overheated.<\/li>\n<li><strong>Somnolence\/Sedation<\/strong>: Somnolence and sedation were commonly reported adverse reactions in clinical studies with clonidine hydrochloride extended-release tablets. Caution patients against operating heavy equipment or driving until they know how they respond to treatment with ONYDA XR. Advise patients to avoid use with alcohol.<\/li>\n<li><strong>Cardiac Conduction Abnormalities:<\/strong> The sympatholytic action of clonidine may worsen sinus node dysfunction and atrioventricular (AV) block, especially in patients taking other sympatholytic drugs. There have been post-marketing reports of patients with conduction abnormalities and\/or taking other sympatholytic drugs who developed severe bradycardia requiring intravenous (IV) atropine, IV isoproterenol, and temporary cardiac pacing while taking clonidine. Titrate ONYDA XR slowly and monitor vital signs frequently in patients with cardiac conduction abnormalities or patients concomitantly treated with other sympatholytic drugs.<\/li>\n<\/ul>\n<p><strong>\u00a0<\/strong><strong>Adverse Reactions: <\/strong><\/p>\n<ul>\n<li>Most common adverse reactions (incidence at least 5% and twice the rate of placebo) as monotherapy in ADHD: somnolence, fatigue, irritability, nightmare, insomnia, constipation, dry mouth.<\/li>\n<li>Most common adverse reactions (incidence at least 5% and twice the rate of placebo) as adjunct therapy to psychostimulant in ADHD: somnolence, fatigue, decreased appetite, dizziness.<\/li>\n<\/ul>\n<p><strong>\u00a0<\/strong><strong>Drug Interactions:<\/strong><\/p>\n<ul>\n<li>CNS Depressants: Clonidine may potentiate the CNS-depressive effects of alcohol, barbiturates, or other sedating drugs. Avoid concomitant use of CNS depressants with ONYDA XR.<\/li>\n<li>Tricyclic Antidepressants: Concomitant use of tricyclic antidepressants with clonidine can increase blood pressure and may counteract the hypotensive effects of clonidine. Monitor blood pressure and adjust dosage of ONYDA XR as needed.<\/li>\n<li>Drugs Known to Affect Sinus Node Function or AV Nodal Conduction: Avoid use of ONYDA XR with agents known to affect sinus node function or AV nodal conduction (e.g., digitalis, calcium channel blockers and beta-blockers) due to a potential for additive effects such as bradycardia and AV block.<\/li>\n<li>Antihypertensive drugs: Concomitant use of antihypertensive drugs with clonidine potentiates the hypotensive effects of clonidine. Monitor blood pressure and heart rate and adjust dosage of ONYDA XR accordingly in patients treated concomitantly with antihypertensives.<\/li>\n<\/ul>\n<p><strong>\u00a0<\/strong><strong>Use in specific population:<\/strong><\/p>\n<ul>\n<li>Use in patients with renal Impairment: The impact of renal impairment on the pharmacokinetics of clonidine in pediatric patients has not been assessed. The dosage of ONYDA XR must be adjusted according to the degree of impairment, and patients should be carefully monitored.<\/li>\n<li>Use during pregnancy: Prolonged experience with clonidine in pregnant women over several decades, based on published literature, including controlled trials, a retrospective cohort study and case reports, have not identified a drug associated risk of major birth defects, miscarriage, and adverse maternal or fetal outcomes.<br \/>\nTo monitor pregnancy outcomes in women exposed to ADHD medications, including ONYDA XR, during pregnancy, healthcare providers are encouraged to register patients by calling the National Pregnancy Registry for Psychiatric Medications at 1-866-961-2388 or visiting online at <a href=\"https:\/\/womensmentalhealth.org\/adhd-medications\/\" target=\"_blank\" rel=\"noopener\">https:\/\/womensmentalhealth.org\/adhd-medications\/<\/a>.<\/li>\n<li>Use during lactation: The developmental and health benefits of breastfeeding should be considered along with the mother\u2019s clinical need for ONYDA XR and any potential adverse effects on the breastfed child from ONYDA XR or from the underlying maternal condition. Monitor breastfeeding infants exposed to ONYDA XR through breast milk for symptoms of hypotension and\/or bradycardia such as sedation, lethargy, tachypnea, and poor feeding.<\/li>\n<\/ul>\n<p><strong><em>To report SUSPECTED ADVERSE REACTIONS, contact Tris Pharma, Inc. at 1-732-940-0358 or FDA at 1-800-FDA-1088 or <\/em><\/strong><a href=\"http:\/\/www.fda.gov\/medwatch\" target=\"_blank\" rel=\"noopener\">www.fda.gov\/medwatch<\/a><\/p>\n<p><strong>Please see <\/strong><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2024\/217645s000lbl.pdf\" target=\"_blank\" rel=\"noopener\"><strong>ONYDA PI<\/strong><\/a><strong> for full prescribing information <\/strong><\/p>\n<p><strong>Company Contact<br \/>\n<\/strong>Cheryl Patnick<br \/>\nTris Pharma, Inc.<br \/>\n<a href=\"mailto:cpatnick@trispharma.com\">cpatnick@trispharma.com<\/a><\/p>\n<p><strong>Media Contact<br \/>\n<\/strong>Laura Morgan<br \/>\nSam Brown, Inc.<br \/>\n951.333.9110<br \/>\n<a href=\"mailto:lauramorgan@sambrown.com\">lauramorgan@sambrown.com<\/a>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text css=&#8221;&#8221;] \u2013 ONYDA XR is the first-and-only liquid non-stimulant ADHD medication available in the United States\u00a0\u2013\u00a0 \u2013 Once-a-day, nighttime dosing and extended-release profile fulfill critical unmet needs in pediatric ADHD patients six years and older \u2013 MONMOUTH JUNCTION, NJ, October 1, 2024 \u2013 Business Wire \u2013 Tris Pharma, Inc. (Tris), a commercial-stage biopharmaceutical company [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_wp_rev_ctl_limit":""},"categories":[1],"tags":[],"class_list":["post-3193","post","type-post","status-publish","format-standard","hentry","category-uncategorised"],"acf":[],"featured_image_src":{"landsacpe":false,"list":false,"medium":false,"full":false},"yoast_head":"\n<title>Tris Pharma\u2019s Once-Daily ADHD Medication, ONYDA XR (clonidine hydrochloride) Extended-Release Oral Suspension, Now Available in the United States<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.trispharma.com\/tris-pharmas-once-daily-adhd-medication-onyda-xr-clonidine-hydrochloride-extended-release-oral-suspension-now-available-in-the-united-states\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tris Pharma\u2019s Once-Daily ADHD Medication, ONYDA XR (clonidine hydrochloride) Extended-Release Oral Suspension, Now Available in the United States\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][vc_column_text css=&#8221;&#8221;] \u2013 ONYDA XR is the first-and-only liquid non-stimulant ADHD medication available in the United States\u00a0\u2013\u00a0 \u2013 Once-a-day, nighttime dosing and extended-release profile fulfill critical unmet needs in pediatric ADHD patients six years and older \u2013 MONMOUTH JUNCTION, NJ, October 1, 2024 \u2013 Business Wire \u2013 Tris Pharma, Inc. 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