{"id":3129,"date":"2024-08-28T02:27:36","date_gmt":"2024-08-28T06:27:36","guid":{"rendered":"https:\/\/www.trispharma.com\/?page_id=3129"},"modified":"2024-08-28T02:57:49","modified_gmt":"2024-08-28T06:57:49","slug":"addiction","status":"publish","type":"page","link":"https:\/\/www.trispharma.com\/innovation\/addiction\/","title":{"rendered":"Addiction"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row full_width=&#8221;stretch_row&#8221; video_bg=&#8221;yes&#8221; video_bg_url=&#8221;\/wp-content\/uploads\/2024\/08\/Tris-addiction-background.mp4&#8243; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221; el_class=&#8221;video-bl-bg grad-over-video add-bg-main adj-video-add&#8221; css=&#8221;.vc_custom_1724826454240{background-image: url(https:\/\/www.trispharma.com\/wp-content\/uploads\/2024\/08\/Tris-addiction-background.jpg?id=3131) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}&#8221;][vc_column width=&#8221;1\/2&#8243;][\/vc_column][vc_column width=&#8221;1\/2&#8243; el_class=&#8221;col-bl-bg&#8221; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221;][vc_column_text css=&#8221;&#8221; el_class=&#8221;text-inno text-white&#8221;]<\/p>\n<h1>Opioid addiction is a <span class=\"org-text\">devastating global challenge <\/span>that requires disruptive solutions<\/h1>\n<p>[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1721990520102{margin-bottom: 0px !important;}&#8221; el_class=&#8221;text-white&#8221;]The opioid addiction crisis is a complex problem that needs innovative solutions, including safer, more effective treatments. Based on promising early data, Tris is evaluating the potential of its investigational medication cebranopadol to treat opioid use disorder (OUD), which could help change the trajectory of the millions of lives affected by this disease.[\/vc_column_text][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row&#8221; wrap_container=&#8221;yes&#8221; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221; el_class=&#8221;subpage-nav hide-mobile&#8221;][vc_column]<div class=\"widget_sidebar_menu main-sidebar-menu wpb_custom_fa56fd63c3b694fcdb3812eb30a338f1\"><div class=\"sidebar-menu-wrap\"><ul id=\"menu-innovation-subnav\" class=\"sidebar-menu\"><li id=\"nav-menu-item-484\" class=\"menu-item menu-item-type-post_type menu-item-object-page  narrow \"><a href=\"https:\/\/www.trispharma.com\/innovation\/\">Overview<\/a><\/li>\n<li id=\"nav-menu-item-485\" class=\"menu-item menu-item-type-post_type menu-item-object-page  narrow \"><a href=\"https:\/\/www.trispharma.com\/innovation\/adhd\/\">ADHD<\/a><\/li>\n<li id=\"nav-menu-item-487\" class=\"menu-item menu-item-type-post_type menu-item-object-page  narrow \"><a href=\"https:\/\/www.trispharma.com\/innovation\/pain\/\">Pain<\/a><\/li>\n<li id=\"nav-menu-item-3138\" class=\"menu-item menu-item-type-post_type menu-item-object-page  narrow \"><a href=\"https:\/\/www.trispharma.com\/innovation\/addiction\/\">Addiction<\/a><\/li>\n<li id=\"nav-menu-item-486\" class=\"menu-item menu-item-type-post_type menu-item-object-page  narrow \"><a href=\"https:\/\/www.trispharma.com\/innovation\/technologies\/\">Technologies<\/a><\/li>\n<\/ul><\/div><\/div>[\/vc_column][\/vc_row][vc_row conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221; css=&#8221;.vc_custom_1722421074878{padding-top: 55px !important;padding-bottom: 10px !important;}&#8221; el_class=&#8221;subpage-first-row-text subpage-first-row&#8221;][vc_column][vc_column_text css=&#8221;&#8221; el_class=&#8221;full-text-line&#8221;]<\/p>\n<h2>The Global Impact of Opioid Addiction<\/h2>\n<p>[\/vc_column_text][vc_column_text css=&#8221;&#8221;]Overuse, misuse and dependence on opioids is having a devastating impact on individuals, families and communities worldwide. Current treatment options for OUD have been insufficient to address this public health crisis, and new approaches are desperately needed. In addition to its unique potential in <a href=\"\/innovation\/pain\/\"><span class=\"blue-highlight\">pain management<\/span><\/a>, Tris\u2019 investigational medication cebranopadol has demonstrated potential to safely and effectively treat OUD.[\/vc_column_text][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row_content&#8221; el_class=&#8221;brain-bg&#8221; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221;][vc_column el_class=&#8221;col-brain&#8221; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221;][vc_column_text css=&#8221;&#8221; el_class=&#8221;text-white text-mac&#8221;]<\/p>\n<h2 style=\"text-align: center;\">Opioid Misuse and The Addiction Crisis<\/h2>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row&#8221; wrap_container=&#8221;yes&#8221; animation_duration=&#8221;3000&#8243; css=&#8221;.vc_custom_1721994940414{padding-bottom: 40px !important;background-color: #02192e !important;}&#8221; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221;][vc_column css=&#8221;.vc_custom_1631805209511{margin-right: 0px !important;margin-left: 0px !important;padding-right: 0px !important;padding-left: 0px !important;}&#8221;][vc_accordion active_tab=&#8221;&#8221; collapsible=&#8221;yes&#8221; type=&#8221;custom&#8221; size=&#8221;panel-group-lg&#8221; skin=&#8221;primary&#8221; use_accordion=&#8221;true&#8221; el_class=&#8221;collapsible-panel collapsible-panel-light add-acc&#8221;][vc_accordion_tab title=&#8221;5 Million&#8221;][vc_column_text css=&#8221;.vc_custom_1722433440216{padding-top: 50px !important;padding-bottom: 10px !important;}&#8221; el_class=&#8221;collapsible-panel-body-copy two-column-textbox-right text-white&#8221;]Number of Americans ages 12 and older who misused opioids in 2020.<sup><a href=\"#notation\">1<\/a><\/sup>[\/vc_column_text][\/vc_accordion_tab][vc_accordion_tab title=&#8221;97.5%&#8221;][vc_column_text css=&#8221;.vc_custom_1723129926552{padding-top: 50px !important;padding-bottom: 10px !important;}&#8221; el_class=&#8221;collapsible-panel-body-copy two-column-textbox-right text-white&#8221;]Percentage of opioid misuse associated with prescription opioids.<sup><a href=\"#notation\">2<\/a><\/sup> Prescription opioid misuse can lead to misuse of other illicit opioids, including heroin and synthetic opioids.[\/vc_column_text][\/vc_accordion_tab][vc_accordion_tab title=&#8221;80%&#8221;][vc_column_text css=&#8221;.vc_custom_1722433481429{padding-top: 50px !important;padding-bottom: 10px !important;}&#8221; el_class=&#8221;collapsible-panel-body-copy two-column-textbox-right text-white&#8221;]Approximate percentage of heroin users who reported using prescription opioids prior to heroin.<sup><a href=\"#notation\">3<\/a><\/sup>[\/vc_column_text][\/vc_accordion_tab][vc_accordion_tab title=&#8221;82,000&#8243;][vc_column_text css=&#8221;.vc_custom_1722433511603{padding-top: 50px !important;padding-bottom: 10px !important;}&#8221; el_class=&#8221;collapsible-panel-body-copy two-column-textbox-right text-white&#8221;]Number of U.S. deaths resulting from opioid overdose in 2022.<sup><a href=\"#notation\">4<\/a><\/sup>[\/vc_column_text][\/vc_accordion_tab][vc_accordion_tab title=&#8221;$1.5 Trillion&#8221;][vc_column_text css=&#8221;.vc_custom_1722433527101{padding-top: 50px !important;padding-bottom: 10px !important;}&#8221; el_class=&#8221;collapsible-panel-body-copy two-column-textbox-right text-white&#8221;]Estimated cost of overdose deaths in the United States in 2020.<sup><a href=\"#notation\">5<\/a><\/sup>[\/vc_column_text][\/vc_accordion_tab][\/vc_accordion][\/vc_column][\/vc_row][vc_row conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221; css=&#8221;.vc_custom_1722520687409{padding-top: 35px !important;padding-bottom: 35px !important;}&#8221;][vc_column][vc_column_text css=&#8221;&#8221; el_class=&#8221;full-text-line&#8221;]<\/p>\n<h2>New Science Offers a Potential Solution<\/h2>\n<p>[\/vc_column_text][vc_column_text css=&#8221;&#8221;]Opioids cause euphoria and addiction through their interaction with the \u00b5-opioid peptide (MOP) receptor. Current treatments for OUD work primarily by blocking the MOP receptors, leaving fewer receptors free to be stimulated by drugs of abuse. These treatments have well-known limitations, including high risks for overdose, withdrawal symptoms and physical dependence.<\/p>\n<p>As a first-in-class investigational dual nociceptin\/orphanin FQ peptide (NOP) receptor and MOP receptor (dual-NMR) agonist, cebranopadol has the potential to offer a safe and highly effective treatment for OUD. By simultaneously stimulating the NOP and MOP receptors, cebranopadol has demonstrated in preclinical studies that it may block the effects of attempts to misuse opioids and other potentially addictive substances, while also blunting the high and euphoria associated with MOP stimulation. We believe cebranopadol has the potential to become the new standard-of-care treatment for OUD.[\/vc_column_text][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row&#8221; el_class=&#8221;org-bg-sec sp-txt-vid&#8221; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221; css=&#8221;.vc_custom_1721992800262{margin-bottom: 50px !important;}&#8221;][vc_column][vc_column_text css=&#8221;.vc_custom_1722434792366{margin-bottom: 0px !important;}&#8221; el_class=&#8221;text-white text-center text-shadow list-sup-white&#8221;]<\/p>\n<h2>Based on a thorough review of data from preclinical studies, the National Institute on Drug Abuse, part of the National Institutes of Health, has awarded Tris Pharma up to $16.6 million to further evaluate cebranopadol\u2019s potential as a treatment for OUD. Under the grant, Tris will collaborate with renowned addiction experts to complete preclinical through Phase 2 studies.<sup><a href=\"#notation\">*<\/a><\/sup><\/h2>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1721992690421{padding-bottom: 55px !important;}&#8221; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221; el_id=&#8221;notation&#8221; el_class=&#8221;rw-notation&#8221;][vc_column][vc_column_text css=&#8221;.vc_custom_1722440234498{margin-bottom: 0px !important;}&#8221; el_class=&#8221;notation-typo&#8221;]<span class=\"text-wrap\"><sup>1 <\/sup>https:\/\/www.addictionhelp.com\/addiction\/statistics\/.<\/span><br \/>\n<sup>2 <\/sup>Accessed 05\/29\/2024 via online site www. Samhsa.gov.<br \/>\n<sup>3 <\/sup>Accessed on 05\/29\/2024 via online site www.nida.nih.gov.<br \/>\n<sup>4 <\/sup>CDC WONDER Database. Accessed 05\/29\/2024 via online site https:\/\/nida.nih.gov\/research-topics\/trends-statistics\/overdose-death-rates.<br \/>\n<sup>5 <\/sup>Accessed on 05\/29\/2024 via online site www.jec.senate.gov.<\/p>\n<p><sup>* <\/sup>Research reported in this publication was supported by the National Institute on Drug Abuse of the National Institutes of Health under Award Number UG3DA059285. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.[\/vc_column_text][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row&#8221; wrap_container=&#8221;yes&#8221; parallax=&#8221;content-moving&#8221; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221; el_class=&#8221;bottom-collout-addiction gradient-global&#8221;][vc_column width=&#8221;1\/2&#8243; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221;][vc_column_text css=&#8221;.vc_custom_1721992608767{padding-right: 30px !important;}&#8221; el_class=&#8221;text-white quote-width&#8221;]<\/p>\n<h2>We aim to help change the trajectory of the millions of lives affected by OUD.<\/h2>\n<p>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221;][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row full_width=&#8221;stretch_row&#8221; 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el_class=&#8221;text-white&#8221;]The opioid addiction crisis is a complex problem that needs innovative solutions, including safer, more [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":24,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-3129","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\n<title>Addiction - Tris Pharma<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.trispharma.com\/innovation\/addiction\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Addiction - Tris Pharma\" \/>\n<meta property=\"og:description\" content=\"[vc_row full_width=&#8221;stretch_row&#8221; 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